Integrative Physiology Lack of Mitogen-Activated Protein Kinase Phosphatase-1 Protects ApoE-Null Mice Against Atherosclerosis
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چکیده
atherogenesis. Methods and Results: Mice with homozygous deficiency in MKP-1 (MKP-1 / ) were bred with apolipoprotein (Apo)E-deficient mice (ApoE / ) and the 3 MKP-1 genotypes (MKP-1 / /ApoE / ; MKP-1 / /ApoE / and MKP-1 / /ApoE / ) were maintained on a normal chow diet for 16 weeks. The 3 groups of mice exhibited similar body weight and serum lipid profiles; however, both MKP-1 / and MKP-1 / mice had significantly less aortic root atherosclerotic lesion formation than MKP-1 / mice. Less en face lesion was observed in 8-month-old MKP-1 / mice. The reduction in atherosclerosis was accompanied by decreased plasma levels of
منابع مشابه
Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.
RATIONALE Multiple protein kinases have been implicated in cardiovascular disease; however, little is known about the role of their counterparts: the protein phosphatases. OBJECTIVE To test the hypothesis that mitogen-activated protein kinase phosphatase (MKP)-1 is actively involved in atherogenesis. METHODS AND RESULTS Mice with homozygous deficiency in MKP-1 (MKP-1(-/-)) were bred with ap...
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OBJECTIVE Mitogen-activated protein kinase phosphatase-1 (MKP-1) is one of several oxidized-l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC)-induced genes identified in human aortic endothelial cells (HAEC). We previously reported that MKP-1 activity is required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an in vivo role of MKP-1 in atherogenesis ...
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